The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity.

Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K signaling is considered a hallmark of cancer.

The PI3K/AKT pathway is defined as an intracellular signaling cascade that plays a crucial role in regulating cell cycle, proliferation, and survival, with significant implications in cancer development …

3 days ago · Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade

Nov 27, 2025 · The Phosphoinositide 3-Kinase (PI3K)-Akt signaling pathway is a major internal regulator that coordinates responses to external cues. It plays a fundamental role in nearly every physiological …

Jul 21, 2025 · PI3K signaling is integrated with cellular metabolism. The pathway helps cells respond to hormones like insulin, facilitating the uptake of glucose from the bloodstream. It also promotes the …

Human cells express three classes of PI3K enzymes. This Review focuses on the class I PI3Ks, their mechanisms of activation, and the signaling networks in which they participate. There are three class …

Dec 9, 2025 · Pathway Mechanism and Cancer Biology The PI3K/Akt/mTOR pathway functions as a kinase cascade controlling cellular proliferation and apoptosis, closely linked to cell cycle regulation …

Dec 16, 2021 · In this review, we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes, review the current statuses of different PI3K/Akt inhibitors, and introduce combination …

The PI3K/AKT pathway has been shown to be required for an extremely diverse array of cellular activities - most notably cellular proliferation and survival. For example, it was shown to be involved …