Nucleic acids derived from microorganisms or dying host cells are recognized by Toll-like receptor 7 (TLR7), TLR8 and TLR9 in endo-lysosomal compartments. In the cytoplasm, there are several distinct ...
The idea that NK cells can distinguish aberrant cells by recognizing 'absence of the expected', rather than 'presence of the unexpected' emerged more than 25 years ago. Klas Kärre recapitulates how ...
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