Appropriate use of sound science applied at critical junctures will improve efficiency in the high-wire act of drug development. Pharmaceutical companies walk a tightrope in early drug development.
Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came to the fore ...
Proteolysis-targeting chimeras (PROTACs), particularly those incorporating the von Hippel–Lindau (VHL) E3 ligase ligand, present significant physicochemical challenges due to their large molecular ...
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