Cysteine's high potential for nucleophilicity makes the amino acid a potent site of reactivity in proteins, but researchers find it hard to assess the reactivity of a given cysteine sidechain in a sea ...

In a recent study posted to the bioRxiv* preprint server, researchers discovered and optimized cysteine-reactive pyrazoline-based covalent inhibitors for several coronaviruses' main protease (Mpro), ...

Nearly every disease has an inflammatory component, but blood tests can't pinpoint inflammation in specific organs or tissues ...

Inflammation serves crucial biological functions, such as in the response to infections and healing. But persistent or uncontrolled inflammation can cause serious problems, and inflammation has been ...

The metabolic and redox state changes during the transition from an arrested oocyte to a totipotent embryo remain uncharacterized. Here, we applied state-of-the-art, integrated methodologies to ...

CLEVELAND—Nearly every disease has an inflammatory component, but blood tests can’t pinpoint inflammation in specific organs or tissues in the human body. Now researchers at Case Western Reserve ...

Join us for an in-depth webinar on quantitative chemoproteomics with TMT reagents, featuring two distinguished speakers from both academia and industry. This webinar aims to bridge the gap between ...

Contrary to popular belief, antioxidants aren’t a panacea. In fact, recent research in Science suggests that for controlling the growth of prostate cancer, prooxidants may be a better choice. Back in ...