CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

Figure 1: Signal distribution and nucleosome position analysis in the androgen receptor and FOXA1 binding regions identified by ChIP-chip experiments and the TSS. Figure 2: qPCR validation of the ...

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...

Tokyo, April 14 - A research group led by Hitoshi Kurumizaka, a professor of structural biology at Waseda University, unveiled the crystal structure of an overlapping dinucleosome, a newly discovered ...

Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism ...

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the ...

Researchers at the University of California San Diego say they have identified a key factor that partially unravels nucleosomes and thus opens the way for genes to activate. The identification of NDF, ...

The eukaryotic genome can be up to 130 billion base pairs long, but required to fit inside each cell nucleus. To do this, DNA is tightly wrapped around histone proteins in bead-like clusters. Each ...

Reconstructed image of the basic unit of chromatin, the nucleosome. Nucleosomes link together like beads on a string, connected by stretches of linker DNA. To form a condensate, these strings bind ...