MPN-U patients exhibit lower platelet counts and higher venous thrombosis rates compared to ET, with thrombosis often occurring at atypical sites. Genetic analysis shows JAK2 mutations are more common ...
In patients with MPNs, having at least 1 CVRF was associated with a worse OS. In patients with myeloproliferative neoplasms (MPNs), cardiovascular risk factors (CVRFs) appeared predictive of poorer ...
ZRSR2 mutations are linked to JAK2 V617R-driven MPNs but are insufficient alone for disease progression. CRISPR-Cas9 studies showed ZRSR2 loss causes intron retention and transcriptional changes ...
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