Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

For decades, structural biologists shoved what looked like shoddy data in the back of their closets, embarrassed. While attempting to gather the structures of proteins, they would sometimes find that ...

In Greek mythology, Proteus, son of Poseidon and prophetic shepherd of sea-beasts, could foretell the future. The elusive sea god was difficult to capture as he assumed many forms—a lion, a serpent, ...

A protein engineered by University of Washington scientists wraps around its target. (Institute for Protein Design Image) The wiggly targets known to scientists as “intrinsically disordered proteins” ...

Intrinsically disordered proteins (IDPs) make up about 30 percent of our proteome. They are important to many fundamental aspects of biology and disrupted in disease. Since they lack a stable shape, ...

Deep learning tools for protein design can also be used to create molecules that bind to them. Certain peptides, such as intrinsically disordered proteins (IDPs), are challenging to target due to ...

RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions (IDR), reports a new study from Institute of Science Tokyo, Japan. Using ...

A milestone in biology has been achieved thanks to artificial intelligence (AI) machine learning and applied physics. A new peer-reviewed study by researchers affiliated with Harvard John A. Paulson ...

Examining an intrinsically disordered protein: "Re" is the end-to-end distance or height, "Rg" is the radius of gyration or overall size. Proteins are essential for our human body functions. There are ...

Intrinsically disordered proteins must compete for binding to common regulatory targets to carry out their biological functions. Previously, we showed that the activation domains of two disordered ...