The principal novel finding of this study is that lifelong low levels of HDL cholesterol due to genetic variation in HDL cholesterol–related genes are not associated with the increased risk of type 2 ...

Associations of serum lipids with cholelithiasis from Mendelian randomization. (A) Causal effects of genetically−lowered lipids on cholelithiasis. (B) Results of multivariable Mendelian randomization ...

Obesity related to metabolic syndrome was found to have a causal relationship with colorectal cancer (CRC), although this causal relationship did not exist in the opposite direction. A study published ...

The schematic illustrates the comprehensive pipeline for Mendelian randomization analysis, starting with multi-omics data inputs from GWAS, eQTL, and pQTL studies, sourced from major databases such as ...

Data included more than a million participants to find that Alzheimer's risk was up to 76% lower in these cases.

The FDA approved aducanumab based on biomarker data hoping the drug will eventually improve clinical outcomes. Like many in the field, the agency reasons that because brain amyloid deposition precedes ...

In a recent study published in the JAMA Network Open, researchers performed a genetic association study using a Mendelian Randomization (MR) framework to assess associations between genetically ...