Lissencephaly is a severe human neuronal migration defect characterized by a smooth cerebral surface, mental retardation and seizures 1. The LIS1 gene was the first gene cloned in any organism ...

Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein–dynactin complex is unknown. Using electron microscopy, we determined the ...

Movement signals life, and nowhere is this truer than inside a living cell. The millions of proteins and molecules within each of our cells bend, travel and conform in a complex but orchestrated ...

The cell cytoskeleton is modulated by motor proteins, known as dyneins, that generate force and movement on microtubules to control a wealth of biological processes, including motility, cell division, ...

Scientists have made important steps toward understanding how dynein--a "molecular motor"--walks along tube-like structures in the cell to move cellular cargo from the outer structures toward the cell ...

However, they found the dynein moved far more erratically than kinesin. "In contrast to the precise movement of kinesin, dynein movement involves not only forward steps, but also frequent backward ...

The first images of motor proteins in action are published in the journal Nature Communications today. These proteins are vital to complex life, forming the transport infrastructure that allows ...

Dr. Jonas Wilson, MD, Ing. Med. Dynein, one of three cytoskeletal motor protein families, was first identified a half century ago and got its name after the ‘dyne’ (i.e. a unit of force). Motor ...

The smallest proteins travel in our cells, completing deeply important tasks to keep our molecular mechanisms moving. They are responsible for transporting cargo, duplicating cells and more. Now, a ...

These proteins are vital to complex life, forming the transport infrastructure that allows different parts of cells to specialise in particular functions. Until now, the way they move has never been ...