Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance. New ...

Scientists from the Institute of Molecular Genetics of the Czech Academy of Sciences, in collaboration with the Faculty of Science at Charles University, have uncovered a completely new role for the ...

Aire expression in the thymus contributes to immune tolerance by eliminating auto-reactive T cells; insufficient elimination causes autoimmune disorders. The Aire gene was thought to be expressed only ...

The deletion of self-reactive T cells during thymocyte development (a process termed central tolerance) is thought to be mediated mainly by medullary thymic epithelial cells (mTECs) and dendritic ...

Early thymic progenitor (ETP) cells, derived from hematopoietic stem cells in the bone marrow, enter the thymus at the cortical-medullary junction (CMJ), retaining multipotent differentiation ...

The thymus is the organ in which T cells*1) differentiate. T cells express various T cell receptors for reacting with various pathogenic microbes and viruses. However, the thymus generates ...